Hepatic encephalopathy Leave a Comment / By MedBrane / August 3, 2024 Hepatic encephalopathy is caused by: Cumulative effect of microscopic bleeds in the brain caused by the livers impaired coagulation factors synthesis Accumulation of ammonia in blood which crosses the blood brain barrier and affects the CNS High AST and ALT levels in blood caused by liver tissue necrosis High levels of uric acid in blood caused by liver failure Autoimmune reaction caused by chronic or acute hepatitis None Time's up